Posted in | News | Nanomedicine

Nano-molecular Carbohydrate Binding Enhances Efficiency of Stainless Steel Implants

A chemical bonding process developed by a multi-disciplinary team at the University of Alberta and Canada's National Institute for Nanotechnology could enhance functions of stainless steel and enable its use in implanted biomedical devices.

Embedded biomedical devices including cardiac stents are implanted in more than 2 million people annually. Stainless steel is strong, stable and can maintain its shape long after implantation. But if it is implanted in an artery, it can cause blood clotting, or cause allergy to metal ions such as nickel ions.

The University of Alberta CIHR Team is developing Glyconanotechnology for use in transplantation and will create artificial nanomaterials that can change the body's immune response prior to an organ transplant. This will allow for organ transplants across various blood groups. In order to address the complex needs and issues, the team drew on surface science chemistry and engineering, carbohydrate chemistry, and immunology and medicine.

Carbohydrate (sugar) molecules had to be bound to the stainless steel surface to induce the needed interaction with the immune system. Its characteristic makes it difficult to add new functions to stainless steel, especially with the monitored coverage essential for biomedical implants. The Edmonton-based team discovered that surface coating of the steel with a thin layer of glass silica using the Atomic Layer Deposition (ALD) technique could address the non-reactivity of steel. The silica offers a chemical handle, through which the clinically prepared carbohydrate molecules could be bound. The team showed that the carbohydrate molecules coated the steel in the correct orientation to interact with the immune system.



Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Chai, Cameron. (2019, February 12). Nano-molecular Carbohydrate Binding Enhances Efficiency of Stainless Steel Implants. AZoNano. Retrieved on February 25, 2024 from

  • MLA

    Chai, Cameron. "Nano-molecular Carbohydrate Binding Enhances Efficiency of Stainless Steel Implants". AZoNano. 25 February 2024. <>.

  • Chicago

    Chai, Cameron. "Nano-molecular Carbohydrate Binding Enhances Efficiency of Stainless Steel Implants". AZoNano. (accessed February 25, 2024).

  • Harvard

    Chai, Cameron. 2019. Nano-molecular Carbohydrate Binding Enhances Efficiency of Stainless Steel Implants. AZoNano, viewed 25 February 2024,

Tell Us What You Think

Do you have a review, update or anything you would like to add to this news story?

Leave your feedback
Your comment type
Azthena logo powered by Azthena AI

Your AI Assistant finding answers from trusted AZoM content

Azthena logo with the word Azthena

Your AI Powered Scientific Assistant

Hi, I'm Azthena, you can trust me to find commercial scientific answers from

A few things you need to know before we start. Please read and accept to continue.

  • Use of “Azthena” is subject to the terms and conditions of use as set out by OpenAI.
  • Content provided on any AZoNetwork sites are subject to the site Terms & Conditions and Privacy Policy.
  • Large Language Models can make mistakes. Consider checking important information.

Great. Ask your question.

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.