Posted in | Nanomedicine

First Place Poster Presentation Award for Alpha-Particle Nano-Generator Actinium-225 Drug

Actinium Pharmaceuticals, Inc., (API), a private biopharmaceutical company that develops innovative targeted radio-immunotherapeutics, announced that the poster summarizing the results for Phase I study of Actimab-A, its antibody directed alpha emitter drug candidate, has won a first place poster presentation award at the 8th Annual Hematologic Malignancies 2012 Conference held in Houston, TX, from October 10-14.

The award was presented to Dr. Joseph Jurcic of Memorial Sloan Kettering Cancer Center, the Primary Investigator in the trial, by the conference chairmen, Dr. Hagop Kantarjian, Chairman of the Department of Leukemia at MD Anderson Cancer Center and Dr. Emil Freireich of the Developmental Therapeutics department at MD Anderson.

The Hematologic Malignancies Conference is a premier meeting that focuses specifically on new advances and practical clinical applications in the field of hematologic malignancies. Almost 700 physicians and other healthcare specialists attended this year.

Actimab-A is being developed for the front line treatment of acute myeloid leukemia in older patients. The drug candidate was evaluated in a Phase I dose escalating trial at Memorial Sloan Kettering Cancer Center (MSKCC). The poster entitled "Phase I Trial of the Targeted Alpha-Particle Nano-Generator Actinium-225 (225Ac)-Lintuzumab in Acute Myeloid Leukemia (AML)" was presented at the Conference by Dr. Jurcic and summarizes key findings from the trial. The goal of the trial was to determine the maximum tolerated dose (MTD), toxicity, pharmacokinetics, and antileukemic activity of 225Ac-lintuzumab. It was a first-in-man, Phase I, dose-escalation trial.

This is the first study to show that therapy with a targeted a-particle generator is feasible in humans. The study has demonstrated that Actimab-A (Lintuzumab-Ac-225) has significant antileukemic activity across all dose levels and the drug candidate is now being further investigated in a multicenter Phase I/II trial in combination with low-dose cytarabine for older AML patients.

"We are very pleased that such a distinguished forum found the results of our drug candidate so compelling," said Jack Talley, CEO of Actinium. "This is a further confirmation that our development efforts on Actimab-A are progressing quickly and gaining recognition. We expect that our collaboration with Dr. Jurcic and other prominent physicians will continue to bring benefits to AML patients."


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