Scientists at the Texas A&M University Health Science Center (Texas A&M Health) have discovered that a nano-sized carbon material derived from the oxidation of carbon-rich sources could be used to treat Down syndrome and other disorders associated with high levels of hydrogen sulfide.
Hydrogen sulfide (H2S) is mainly known as a byproduct of petroleum production that is characterized by a "rotten egg" smell. This noxious gas is also naturally produced from the anaerobic decomposition, or fermentation, of organic matter - when bacteria break down animal manure, food wastes and other organic matter in the absence of oxygen. Hydrogen sulfide is synthesized in living organisms, where it plays a vital role in bone, brain, liver and kidney function, as well as regulating the dilation of blood vessels and supplementing the electron transport chain.
One of the most well-known conditions associated with high levels of hydrogen sulfide is Down syndrome. This genetic disorder is associated with a decline in function of many systems over time, including the musculoskeletal and nervous systems. Previous studies have hypothesized that reducing the levels of circulating H2S may improve function in individuals with Down syndrome. However, hydrogen sulfide is necessary for normal biological function, so directly inhibiting synthesizing enzymes could be detrimental.
An innovative and collaborative study led by Dr. Thomas A. Kent, the Robert A. Welch Chair Professor at the Texas A&M Health Institute of Biosciences and Technology and the Texas A&M University School of Medicine, reveals how a nano-sized carbon material derived from the oxidation of various carbon-rich sources can act as a mediator of several therapeutic reactions and improve outcomes in experimental models ranging from stroke, bleeding, trauma and mitochondrial toxins. This paper, published in the high-impact journal Advanced Materials, highlights the ability of the carbon nanomaterial to improve function and survival in Down syndrome-derived cells.
The research describes how readily synthesized carbon nanomaterials can provide a novel approach to treat disorders of toxic levels of hydrogen sulfide in disorders like Down syndrome and many others. Rather than blocking its production, hydrogen sulfide is converted into its metabolites that offer many favorable functions such as modifying proteins to improve their ability to act as antioxidants. These materials act as synthetic nano-sized enzymes, termed nanozymes, that so far have not shown any apparent toxicity in several different experimental models and are well tolerated while protecting from both acute and chronic injuries.
"We are excited about this research because we believe we have discovered a way to treat many disorders using carbon-based materials and a straightforward, simple synthesis method," Kent said. "We hope that these materials will provide a new approach to treating disorders of high hydrogen sulfide, by converting them to beneficial metabolites as exemplified by Down syndrome.
"We keep finding new actions, all of which so far are favorable and may be only the tip of the iceberg as to what these materials can do to support important biological functions under conditions in which they are threatened," he continued.
The authors of this study intend to take these materials to market for use in therapies and currently have a patent pending. Researchers from Texas A&M University, Rice University, UTHealth, Indiana University School of Medicine-South Bend, and Houston Methodist Hospital co-authored this study. This work is funded by the Welch Foundation and National Institutes of Health.