Posted in | Nanomaterials | Fullerenes

Carbon Nanotube Based Contrast Agent may Help Diagnostics for Heart Attack Prevention

Luna Innovations Incorporated has been awarded a grant from the National Heart, Lung, and Blood Institute to develop a new diagnostic agent that could improve the diagnosis of coronary artery disease (CAD), a condition that causes most heart attacks. Luna is investigating a carbon nanomaterial-based contrast agent, using its exclusive TRIMETASPHERE® platform, which may provide the ability to use magnetic resonance imaging (MRI) to reveal plaque buildup in the arterial walls of the heart and possibly provide fine structural detail of the plaque.

Coronary arteries supply blood and oxygen to the heart. CAD occurs when the arteries harden and narrow as plaque builds up on the interior walls, a condition known as atherosclerosis. In most people, plaque is stable, however; plaque can break off and form a blood clot which may block the flow of blood to the heart ultimately, leading to a heart attack. CAD is the most common type of heart disease and is the leading cause of death in the United States. Technologies that can allow medical personnel to better assess how much plaque buildup has occurred can improve the management of patients with CAD.

Currently, CAD is most-commonly diagnosed through cardiac catheterization angiography. In this method, a flexible tube is passed through an artery in the groin or arm to reach the coronary arteries. An x-ray blocking dye is then injected through the tube into the coronary arteries that allows the doctor to see by x-ray obstructions that hinder or prevent flow of blood through the heart and the location of blockages.

“Luna’s MRI contrast agent targeted to arterial plaque may provide information that cannot be obtained with x-rays, such as the status of plaque in smaller arteries,” explained Robert Lenk, President of Luna’s nanoWorks division in Danville, VA. “Recent evidence, such as the WISE trial, a study on Women’s Ischemica Syndrome Evaluation sponsored by the National Institutes of Health, indicated that plaque buildup in smaller arteries is important in managing CAD, especially for women’s health.”

“Our company is engaged in the discovery, licensing and development of unique intellectual property, with an eye on moving science to solutions,” said Kent Murphy, CEO and Chairman of Luna Innovations. “Our Trimetasphere is a metallofullerene technology that has a unique behavior enabling us to improve and expand product performance in many areas, of which the most important is MRI.”

Additionally, Luna’s contrast agent under development is anticipated to give a physician improved diagnostic performance and safety over current gadolinium-containing contrast agents used in MRI. Preliminary tests indicate that the unique structure of the TRIMETASPHERE®-based agent encloses the metallic signal molecule in such a way that it cannot escape and cause harm to the patient. This enhanced safety is due to the nature of the TRIMETASPHERE® molecule, how it behaves in the magnetic field, and the encapsulation of the metals protecting patients from metal poisoning.

The introduction of TRIMETASPHERE®-based contrast agents may help prevent the recently discovered disease, Nephrogenic Systemic Fibrosis / Nephrogenic Fibrosing Dermopathy (NSF/NFD), which has been attributed to current gadolinium-based contrast agents used in MRI procedures. MRI is a non-invasive diagnostic procedure that enables physicians to visualize internal organs through magnetic interactions. This procedure may be enhanced by the use of contrast agents that improve the resolution of soft tissue structures inside the patient. However, some MRI contrast agents can be harmful to a patient. Since June 2006, the U.S. Food and Drug Administration has been reviewing reports about patients who have developed NSF/NFD after receiving a gadolinium-based contrast agent during an MRI scan. The cause of this rare and dangerous condition is not fully understood. NSF/NFD can cause severe joint problems, skin problems, kidney failure, or renal failure. In May, Federal health officials issued a black box warning for the current gadolinium-based contrast agents used in MRI to heighten awareness about the risk of NSF/NFD in patients with kidney problems. Luna’s new technology, using the carbon nanomaterial known as TRIMETASPHERE®, may eliminate this problem.

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