Posted in | News | Nanotoxicology | Nanobusiness

NanoViricides Anti-HIV Drug Candidate Demonstrated Superior Survival Time

NanoViricides, Inc., said that its lead anti-HIV drug candidate demonstrated markedly superior survival results in the test animals when compared to those animals given the anti-HIV "combo cocktail" in a double-blind animal study. The three-drug combo "cocktail" used for comparison is one of the most frequently used triple combination therapies in humans.

The Company reported that the best nanoviricide anti-HIV drug candidate improved total hours of survival time by 99% with respect to appropriate controls. In contrast, the combo therapy improved survival hours by only 52%. Furthermore, AZT, the first drug used in humans to treat HIV/AIDS, failed to show any survival improvement, as was expected, in this lethality-based animal model study.

The Company also reported that the average body weight loss, a measure of the degree of illness in the experimental subjects, was only 11.4% after treatment with this nanoviricide drug candidate, as compared to 12.9% in those treated with the combo cocktail, and to 23% average body weight loss seen in the untreated control mice.

“We believe these are dramatic results,” said Eugene Seymour, MD, MPH, CEO of the Company, adding that “if these results can be duplicated in humans, triple combo therapy with its toxic side effects may well be replaced in the near future with a much safer single HivCide-I ™ nanoviricide therapy.”

“Another advantage of the HivCide-I nanoviricide is that the treatment can be combined with other existing drug regimens for substantial added benefits,” said Anil R. Diwan, PhD, President of the Company and inventor of the technology, explaining further that “strong improvements should be possible when a nanoviricide is combined with conventional regimen because nanoviricides are designed to act by a novel and completely different mechanism from existing anti-retroviral drugs.”
“As for vaccines [against HIV], it was difficult to predict when they would be developed, but it could be some 10 years from the present time,” remarked Dr. Anthony S. Fauci, M.D., Director of the National Institute of Allergy and Infectious Diseases, at the United Nations General Assembly High Level HIV/AIDS Meeting held on June 10 ( Several high level officials have stressed the need for development of better drugs against HIV. Jean-Francois Delfraissy, Director of France's National Agency for Research on AIDS and Viral Hepatitis, said that research "must continue to develop new therapeutic strategies," in Senegal on May 27, according to xinhuanet (

AZT is a well known anti-retroviral nucleoside reverse transcriptase inhibitor (NRTI). The combo cocktail employed as a positive control in this study consisted of AZT, 3TC (another NRTI), and Crixivan® (Merck, a Protease Inhibitor), administered orally. All other drugs were administered as injections. Treatment was started 24 hrs after the mice were infected with high (1200 LD50) levels of mouse-adapted HIV-I virus particles. Treatment was repeated twice more at 48 hr intervals.

The studies were performed at a Bio-Safety Level 3 Laboratory (BSL-3) facility in Boston, MA. These mouse model studies were conducted by Dr. Krishna Menon, PhD, VMD, MRCS, a world-renowned authority in preclinical and toxicological studies of innovative therapeutics. The Company plans to report additional results from this study as they become available over the next several weeks. The Company is now designing additional studies with the objective of filing an investigational new drug application (IND) to the FDA in the future.


Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    NanoViricides, Inc. (2019, February 15). NanoViricides Anti-HIV Drug Candidate Demonstrated Superior Survival Time. AZoNano. Retrieved on April 20, 2024 from

  • MLA

    NanoViricides, Inc. "NanoViricides Anti-HIV Drug Candidate Demonstrated Superior Survival Time". AZoNano. 20 April 2024. <>.

  • Chicago

    NanoViricides, Inc. "NanoViricides Anti-HIV Drug Candidate Demonstrated Superior Survival Time". AZoNano. (accessed April 20, 2024).

  • Harvard

    NanoViricides, Inc. 2019. NanoViricides Anti-HIV Drug Candidate Demonstrated Superior Survival Time. AZoNano, viewed 20 April 2024,

Tell Us What You Think

Do you have a review, update or anything you would like to add to this news story?

Leave your feedback
Your comment type

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.