are delighted to be invited to join a new research consortium called "INTOPSENS"
combining leading research centres with industry across Europe. Intopsens will
develop a highly integrated optical sensor for point of care label free identification
of sepsis bacteria strains and their antibiotic resistance. The European Union
will support the consortium with 2.6 MEuro, through its EU Seventh Framework
Sepsis is a serious medical condition characterized by a whole-body inflammatory
state caused by infection. The body develops this inflammatory response to micro-organisms
in the blood, more commonly defined as blood poisoning. Sepsis can lead to septic
shock, multiple organ dysfunction syndrome and death, with an associated 7%
rise in mortality for every hour delay in the administration of appropriate
antibiotic therapy. Sepsis reflects the current threat of multi-antibiotic resistant
bacteria such as MRSA, making treatment extremely difficult and greatly reducing
the efficacy of the wide range of antibiotic treatments that are available.
The identification of the causative microbe in sepsis provides key data on the
Evidently, a diagnostic platform is needed that can quickly identify the presence
and type of infectious micro-organism, as well as the type of antibiotic resistance
genes that it carries, so as to be able to proscribe the correct type of antimicrobial
treatment. Ideally it should be a rapid system with little hands-on time, so
as to be used at point of care (PoC) in an intensive care unit by paramedics
and GPs, says Wouter van der Wijngaart, Associate Professor at the Microsystem
Technology Lab at KTH, and also Intopsens Project Manager.
The Intopsens consortium will develop a bench-top readout system and disposable
lab-on-chip cartridges for detection of the bacteria and their antibiotic susceptibility
from whole blood using ultrasensitive photonic biosensors.
In addition to Farfield, the Consortium partners include KTH - Royal Institute
of Technology (project coordinator, SE) Universidad Politécnica de Valencia
(ES) Århus University, Interdisciplinary Nanoscience Center (DK) Universiteit
Antwerpen (BE) Universiteit Gent (BE) Mobidiag Ltd (FI).