Next Generation Multiple Sclerosis Drug Based on "Buckyballs"

If you're of a certain age, you'll remember Buckminster Fuller's distinctive "geodesic domes" - soccer-ball-shaped structures that the late futurist envisioned as ideal human domiciles. Tel Aviv University chemists remember them too - and are now putting them to use in the treatment of multiple sclerosis (MS).

This is Dr. Michael Gozin from Tel Aviv University. Credit: AFTAU

In partnership with a group of Prof. Howard Weiner from Brigham and Women's Hospital at Harvard Medical School, Dr. Michael Gozin from TAU's School of Chemistry is attempting to create the next generation MS drug based on a delivery platform of "buckyballs," small soccer-ball-shaped molecules sometimes called fullerenes. Made from pure carbon, the buckyballs can function as invigorating antioxidants to keep neurons in the brain alive and kicking.

There is currently no cure for MS, which slowly paralyzes and then kills.

Buckyballs and related carbon nanotubes have enormous potential to be used in sensors and electronic applications allowing scientists to manufacture much more smaller and faster processors. These carbon-based materials have a huge range of possibilities in nanotechnology applications as well.

Until now, buckyball-derived therapeutics have not been used in medicine. But the TAU and Harvard teams believe that they may resolve issues related to this nanomaterial development, and are seeking to commercialize their patented invention. If successful, the TAU-Harvard collaboration could provide new hope to millions of MS sufferers, and would make Bucky himself proud.

On the Medicine Ball

The TAU team is the first in the world to have synthesized a brain-targeted antioxidant to treat affected neurons in the brain. Pre-clinical trials, the researchers report, proved successful in animal models. They are also attempting to apply the same technology to the treatment of Alzheimers disease, but a reliable and effective treatment for MS is their primary goal.

MS is an autoimmune disease that robs people of the ability to control their motor movements. No one knows exactly how many people are afflicted with MS. According to the National Institute of Neurological Disorders and Stroke, it is estimated that there are currently more than 350,000 people in the United States, who have been diagnosed with MS, where approximately 200 new cases are diagnosed each week. Current state-of-the-art therapies like the Israeli-invented Copaxone clearly help, but may not be enough, says Dr. Gozin, whose wide-ranging research has included work on classified projects for the U.S. Department of Defense.

"Multiple sclerosis is a very serious clinical condition," says Dr. Gozin. "I had a dream, an idea for a new kind of drug." He took this idea to MS expert Prof. Howard Weiner at Harvard University, and the two began a collaboration.

"I wanted to target with antioxidants specific receptors in the brain, which are involved in the disease progress, to stall the deterioration of motor function in MS sufferers," Dr. Gozin says. The US-Israeli researchers started from the belief that buckyballs, and brain-targeted moieties attached to them, may be able to achieve success in treating MS.

A Dose of C60

"We've created a molecule based on the C60 fullerene, a soccer-ball-shape, with great biomedical potential," says Dr. Gozin. The Tel Aviv University team, including graduate student Amnon Bar-Shir, was the first to synthesize and patent this application, which is "programmed" to target specific receptors in the brain. "We are presently working on the next generation of this type of molecules, containing less exotic and more natural building blocks," Dr. Gozin reports.

Tell Us What You Think

Do you have a review, update or anything you would like to add to this news story?

Leave your feedback
Your comment type
Submit
Azthena logo

AZoM.com powered by Azthena AI

Your AI Assistant finding answers from trusted AZoM content

Azthena logo with the word Azthena

Your AI Powered Scientific Assistant

Hi, I'm Azthena, you can trust me to find commercial scientific answers from AZoNetwork.com.

A few things you need to know before we start. Please read and accept to continue.

  • Use of “Azthena” is subject to the terms and conditions of use as set out by OpenAI.
  • Content provided on any AZoNetwork sites are subject to the site Terms & Conditions and Privacy Policy.
  • Large Language Models can make mistakes. Consider checking important information.

Great. Ask your question.

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.