Top Institute Pharma has developed technology to enable medicines to be absorbed into the blood much faster, increasing their efficiency.
Scientist, Hans de Waard at the University of Groningen, has selected this subject for his doctoral thesis. De Waard said many medicines do not dissolve in the digestive tract, so they do not reach the bloodstream. This reduces efficiency. But nanoparticles of these medicines are dissolved easily. The medicines include diazepam (valium), ibuprofen, and the cholesterol-reducing fenofibrate. The findings will not only reduce dosages but also potential side-effects.
Medicines will be broken into small particles, especially those taken orally but do not dissolve in water. De Waard says the medicines still being developed will benefit from this technology. At present, most of the medication does not enter the blood stream, resulting in physicians prescribing larger doses that could cause serious side effects.
This research is part of a project at Top Institute Pharma that is exploring efficacy of medication for brain disease. Others collaborating on the project include Abbott Healthcare Products BV, Radboud University Nijmegen, Radboud University Nijmegen Medical Center, University Medical Center Groningen, the University of Groningen, Leiden University and Utrecht University.