Reliable Nano Particle Size and Stability Analysis in Opaque Suspensions and Emulsions | NANOPHOX

The NANOPHOX offers nano particle size analysis in opaque suspensions based on dynamic light scattering from 0.5 nm to 10,000 nm.

In general, the principle of dynamic light scattering (DLS) allows for the acquisition of scattered light intensities of particles under thermal motion for nanoparticle characterization. NANOPHOX brings Photon Cross-Correlation Spectroscopy (PCCS) to life, allowing for high resolution nanoparticle size analysis in high concentrated suspensions and emulsions ranging from 0.5 nm to 10,000 nm with minimum sample preparation. Nanoparticle size, size distribution and polydispersity are as reliably analyzed with this method of DLS, as are the stability of dispersion.

The application of cross-correlation technology allows the calculation of the particle size distribution by eliminating the effect of multiple scattering. The amplitude of the cross-correlation function - which depends on the multiple scattering - provides direct measurement of changes in particle number and size. Differentiating measurements of agglomeration and sedimentation behavior as well as special effects such as particle-particle interactions and changes in viscosity of high concentrated samples now become feasible.

NANOPHOX is ideally suited for research and development as well as for industrial quality control. Typical uses include polymer suspensions and emulsions, pharmaceutical emulsions, inks and research on nanomaterials in general. In pharmacy and biochemistry nanoparticles serve as API carriers or can be charged with molecules for targeted drug delivery. NANOPHOX together with its powerful PAQXOS control and evaluation software is fully compliant with FDA requirements and 21 CFR Rule 11.

Set-up of NANOPHOX basing on PCCS using two incident laser beams, two photodetectors and a correlator

Set-up of NANOPHOX basing on PCCS using two incident laser beams, two photodetectors and a correlator

Traditional DLS is obtained with Photon Correlation Spectroscopy (PCS) which uses auto-correlation of scattered light intensities to determine particle size distribution. This conventional technology requires extremely diluted samples in order to deliver meaningful results. The innovative PCCS technology will help to eliminate the influence of multiple scattered light in principle. It acquires two separately induced scattered light intensities, and by the cross correlation of both signals, the single scattered light - used for the correct calculation of the particle size distribution - is filtered out from the multiple scattered light part. The single scattered light is therefore separated from the multiple scattered light, so a single scattering signal is sufficient to start the particle size analysis.

Feature highlights

  • Particle size and particle size distribution as well as stability behavior
  • For nanoparticles in turbid suspensions and emulsions
  • For analyses in research, development or quality laboratories
  • Robust method for measuring range from 0.5 nm to 10,000 nm
  • Samples concentration from 0.0001 Vol.-% to approx. 20 Vol.-%
  • Concentration independent particle characterization by elimination of multiple scattering
    effects | Reduction of sample preparation errors
  • Insensitive to sample contamination
  • High sensitivity for changes in size and measurement of bimodal distributions
  • Solid-state measuring method for in-situ observation of changes in stability or size, e.g. growth and crystallization processes

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