A candid photo can reveal much more about the mood of a party than a stiff, posed picture. The same might be true for molecules, according to researchers. In a report appearing in the journal ACS Central Science, they report use of a newly developed method that can take a candid snapshot of how molecules really move in vitro and in cells. This information could help resolve some controversial claims about how nanocrystals assemble.
Scientists at Albert Einstein College of Medicine of Yeshiva University and their international collaborators have developed a novel fluorescence microscopy technique that for the first time shows where and when proteins are produced. The technique allows researchers to directly observe individual messenger RNA molecules (mRNAs) as they are translated into proteins in living cells.
Leica Microsystems launches Leica EM Cryo CLEM, a system that facilitates correlative light and electron microscopy (CLEM).
A new technique to create tissue-engineered bladders has been shown to decrease scarring and significantly increase tissue growth. The bladders are produced using scaffolds coated with anti-inflammatory peptides.
JPK Instruments, a world-leading manufacturer of nanoanalytic instrumentation for research in life sciences and soft matter, reports on the use of their NanoTracker™ optical tweezers system to study collagen fibrils at Illinois Institute of Technology in Chicago.
When a salmonella bacterium attacks a cell, it uses a nanoscopic needle to inject it with proteins to aid the infection. If the needle is too short, the cell won’t be infected. Too long, and the needle breaks. Now, University of Utah biologists report how a disposable molecular ruler or tape measure determines the length of the bacterial needle so it is just right.
Light can be used to activate normal, non-genetically modified neurons through the use of targeted gold nanoparticles, report scientists from the University of Chicago and the University of Illinois at Chicago. The new technique, described in the journal Neuron on March 12, represents a significant technological advance with potential advantages over current optogenetic methods, including possible use in the development of therapeutics toward diseases such as macular degeneration.
Scientists at Johns Hopkins have created a 3-D model of a complex protein machine, ORC, which helps prepare DNA to be duplicated. Like an image of a criminal suspect, the intricate model of ORC has helped build a "profile" of the activities of this crucial "protein of interest." But the new information has uncovered another mystery: ORC's structure reveals that it is not always "on" as was previously thought, and no one knows how it turns on and off.
In 1953 Watson and Crick first published the discovery of the double helix structure of the DNA. They were able to visualize the DNA structure by means of X-Ray diffraction. Techniques, such as electron microscopy, allowed scientists to identify nucleosomes, the first and most basic level of chromosome organisation. Until now it was known that our DNA is packaged by regular repeating units of those nucleosomes throughout the genome giving rise to chromatin.
Infection with highly contagious noroviruses, while not usually fatal, can lead to a slew of unpleasant symptoms such as excessive vomiting and diarrhea. Current treatment options are limited to rehydration of the patient. "Additionally, noroviruses come in a variety of constantly evolving strains. This makes the development of an effective vaccine to protect against infection, as well as antiviral therapy to combat already-existing infections, particularly challenging", says Dr. Grant Hansman, a virologist who leads the CHS Research Group on Noroviruses at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) and Heidelberg University.
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