Postnova Analytics reports on the recent investment by the Department of Chemistry at University College London (UCL) in an AF2000 Field Flow Fractionation System to assist them in their development of novel nanoscale vehicles for drug delivery.
UCL has pioneered the engineering of novel nanoscale drug delivery vehicles which can be tuned to release a range of cargos. The drug delivery system is based upon the synthesis of self-assembled spherical polymer vesicles known as polymersomes. Polymersomes are biocompatible and stable making them ideal for the development of drug delivery systems.
Researchers at UCL purchased the Postnova AF2000 system to work on the purification and characterisation of polymersomes being synthesised for the treatment of several diseases including cancer, infections and neurological disorders. The project is part of a multidisciplinary effort aimed toward the design of personalised nanomedicines. We are delighted to provide UCL with an analytical tool that will assist them in their ground breaking work.
Paul Clarke, Managing Director of Postnova Analytics (UK) Ltd.
Having identified Field Flow Fractionation as the best technique to purify and characterise polymersomes we elected to purchase an AF2000 system from Postnova as it allows us to quantify the materials both in terms of size as well as shape. Such an effort is critical to both elucidate important structure/function relation as well as to expedite the necessary quality control associated with clinical translation.
Guiseppe Battaglia, Professor of Molecular Bionics, within the Chemistry Department at UCL
The Postnova AF2000 is a high performance Field Flow Fractionation (FFF) platform for separation of proteins, macromolecules and nanoparticles. Modular in design, the AF2000 incorporates the combined experience, expertise and technological advances from Postnova Analytics' nearly two decades of leadership in FFF.
Incorporating a range of FFF modules in a single integrated system to provide universal separation, the AF2000 offers more flexibility, better performance and more robust results than any system before.
For further information on the AF2000 please visit www.postnova.com/af2000-overview.html or contact Postnova Analytics on +44-1885-475007 / [email protected].
The Department of Chemistry at University College London is one of the top chemistry departments in the UK, with over 50 members of academic staff carrying out world-leading research.
The Molecular Bionics research group, headed by Professor Battaglia, is a multidisciplinary group comprising scientists and engineers from different background all working together to the design of novel ways to navigate the body and deliver agents in most precise fashion.
About Postnova Analytics
Founded in 1997, Postnova Analytics is the inventor and leading international supplier of Field-Flow Fractionation (FFF) systems for markets including biopharmaceuticals, polymers, materials, nanotechnology and environmental sciences. Leveraging its unique and patented modular FFF - Light Scattering Platform, Postnova has been able to provide high performance solutions to a wide range of applications. Today the company's growing product portfolio includes Flow FFF, Centrifugal FFF, Thermal FFF, Size Exclusion Chromatography (SEC), MALS and DLS Light Scattering. Postnova (www.postnova.com) is located and headquartered in Landsberg am Lech (Germany) and has subsidiaries in the USA, UK and Finland. These offices in conjunction with a highly qualified and trained distribution network provides informed local support to customers worldwide.