Organic-based nanoplatforms are emerging as promising theranostic systems that combine diagnostic imaging with targeted treatment while addressing concerns about the persistence and toxicity of some inorganic nanomaterials. The review shows how molecular composition and nanoscale structure shape drug loading, targeting, imaging, therapeutic activity, biodegradation, and clinical potential across self-assembled, polymeric, lipid-based, carbon-based, and hybrid systems.
Researchers at Argonne are shaping the nanoscience frontier, using atomic-scale control to accelerate advances in electronics, energy storage, catalysis, sensing and medicine.
The device has the potential to last an entire lifetime, reducing the risks and costs associated with replacing the devices when their batteries fail.
A comprehensive review examined how nanomaterials could protect healthy tissues from radiation damage through targeted drug delivery, reactive oxygen species scavenging, anti-inflammatory activity, and physical radiation shielding. Although experimental studies show promising protection across several tissues and organ systems, most approaches remain preclinical, with long-term safety, biodistribution, scalability, and selective protection of healthy tissue still requiring investigation.
Researchers developed modular organ-targeting metal-phenolic network coatings that altered where diverse nanoparticles accumulated after intravenous administration in mice. By tuning metal ions, phenolic ligands, and PEG molecular weight, the researchers redirected nanoparticles toward the lungs, kidneys, heart, and brain while preserving functional mRNA delivery in coated lipid nanoparticles.
Researchers developed a scalable silicon microneedle electrode using mechanical dicing, KOH etching, and nanostructured platinum to improve dry EEG recording without conductive gels. The nanoPt coating increased electrochemically active surface area by about 15-fold, reduced electrode-skin impedance, and improved proof-of-concept EEG signal quality compared with non-nanostructured platinum-coated microneedles, although conventional wet electrodes still performed better.
AI is increasingly being used across precision oncology to accelerate drug discovery, predict resistance, and guide the design of nanoparticle-based drug-delivery systems. The review highlights AI-guided nanocarriers, adaptive treatment strategies, and multi-omics analysis while emphasizing challenges involving data quality, transparency, generalizability, and regulation.
Researchers developed an edge-supported nano-thick epidermal electronics platform that combines an approximately 500 nm sensing region with a reinforced 5 µm scaffold for easier handling, release, and reuse. The design enabled water-assisted release and highly conformal skin sensing, with low-impedance sEMG electrodes, a 0.48 ms temperature sensor, and a pressure sensor reaching 62.9 kPa?¹ sensitivity in its most sensitive range.
Researchers engineered a fuel-driven DNA origami nanosyringe that moves in approximately 14 nm steps to reversibly penetrate model lipid membranes and transport molecular cargo. The device also triggered localized DNA assembly, RNA transcription, and catalytic RNA cleavage inside synthetic cell-like vesicles.
Nanostructured titanium composites may enhance dental implants by providing antibacterial activity, enhanced bioactivity, corrosion protection, and localized drug-delivery capabilities. However, the review found that most evidence remains laboratory or preclinical, and long-term clinical studies are needed before these materials can move beyond established titanium implants.
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