Posted in | News | Nanomedicine | Nanomaterials

Growing Mammalian Cells on Nanowires Provides Novel View of Cell Activity

A research team at the University of California, Berkeley, has achieved a significant step toward one of the futuristic goals of nanomedicine and nanobiology-developing technology for "wiring" together individual cells. This demonstration opens the way to connect cells via nanowires to external sensors and other devices for real-time monitoring of intracellular biochemical processes.

In a study published in the Journal of the American Chemical Society, a team led by Bruce Conklin, Ph.D., and Peidong Yang, Ph.D., report what they claim to be the first demonstration of a direct nanowire connection to individual mammalian cells without the use of force that can damage or kill cells. The investigators connected human embryonic kidney cells and mouse embryonic stem cells to silicon nanowires, using an approach in which the wires penetrated into cells naturally as the cells grew in cultures.

In their paper, the researchers report that the nanowire-impaled cells survived for several days and that they were able to derive and maintain heart muscle cells from the mouse embryonic stem cells. The investigators also were able to use the silicon nanowire array to deliver genes into the impaled cells and then monitor the success of that gene delivery using the silicon nanowires as intracellular sensors.

This work is detailed in the paper "Interfacing silicon nanowires with mammalian cells." Investigators from the Gladstone Institute of Cardiovascular Disease, in San Francisco, also participated in this study. This paper was published online in advance of print publication. An abstract of this paper is available through PubMed. View abstract.

http://nano.cancer.gov

Tell Us What You Think

Do you have a review, update or anything you would like to add to this news story?

Leave your feedback
Your comment type
Submit
Azthena logo

AZoM.com powered by Azthena AI

Your AI Assistant finding answers from trusted AZoM content

Your AI Powered Scientific Assistant

Hi, I'm Azthena, you can trust me to find commercial scientific answers from AZoNetwork.com.

A few things you need to know before we start. Please read and accept to continue.

  • Use of “Azthena” is subject to the terms and conditions of use as set out by OpenAI.
  • Content provided on any AZoNetwork sites are subject to the site Terms & Conditions and Privacy Policy.
  • Large Language Models can make mistakes. Consider checking important information.

Great. Ask your question.

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.